Author/Authors :
Miyashita، نويسنده , , Takanori and Matsumoto، نويسنده , , Noritake and Moriguchi، نويسنده , , Tomohisa and Shinozuka، نويسنده , , Kazuo، نويسنده ,
Abstract :
A novel phosphoramidite synthon of a dinucleoside phosphotriester unit bearing an intercalative moiety at its internucleotide linkage in a stereospecific manner was prepared and successfully incorporated into the middle portion of α-β chimeric oligoDNA. One of the resulting stereoisomeric chimera DNAs strongly enhances the thermal stability of an alternate-stranded triplex formed between the chimera and a double-stranded DNA.
