Author/Authors :
Ito، نويسنده , , Masato and Osaku، نويسنده , , Akihide and Kitahara، نويسنده , , Sachiko and Hirakawa، نويسنده , , Makoto and Ikariya، نويسنده , , Takao، نويسنده ,
Abstract :
A ternary catalyst system of Cp*RuCl(cod)–2-diphenylphosphinoethylamine–KOt-Bu (Cp*=η5-C5(CH3)5, cod=1,5-cyclooctadiene) causes rapid racemization of chiral non-racemic sec-alcohols, which results from the reversible hydrogen transfer between sec-alcohols and ketones. Both tertiary phosphine and primary amine functionalities in the ligand are responsible for the high rate.
