Author/Authors :
Terauchi، نويسنده , , Takeshi and Terauchi، نويسنده , , Taro and Sato، نويسنده , , Ippei and Shoji، نويسنده , , Wataru and Tsukada، نويسنده , , Tomoharu and Tsunoda، نويسنده , , Takashi and Kanoh، نويسنده , , Naoki and Nakata، نويسنده , , Masaya، نويسنده ,
Abstract :
The Mukaiyama aldol coupling of the second-generation C1C14 (AB) fragment of altohyrtins (spongistatins) with the model α-methyl-β-alkoxyaldehydes revealed that the stereochemistry at the newly formed carbon centers was controlled by the β-alkoxy chiral center of the model aldehydes. The union of the AB fragment with the C15C28 (CD) fragment under the same conditions gave the fully elaborated C1C28 (ABCD) subunit in good yield.
Keywords :
altohyrtins , spongistatins , stereoselective synthesis , aldol reaction
