Author/Authors :
MacCoss، نويسنده , , Rachel N. and Balskus، نويسنده , , Emily P. and Ley، نويسنده , , Steven V.، نويسنده ,
Abstract :
A convenient sequential oxidation–olefination protocol is reported using tetra-n-propylammonium perruthenate (TPAP) as oxidant and phosphonium salts as olefin source. The oxidation reaction mixture is added directly to the phosphorane facilitating an efficient method for this transformation that avoids work-up of potentially sensitive aldehyde intermediates.
