Total synthesis of the (+)-antimycin A3 family: structure elucidation of (+)-antimycin A3a

(+)-Antimycin A3a (AA3a), one component of the natural antibiotic antimycin A3, was synthesized using an asymmetric aza-Claisen rearrangement. The stereochemistry at the 2′ position on the acyloxy side chain of AA3a was established as S-configuration by comparison of the synthetic AA3a and the natural AA3a.