Author/Authors :
Hone، نويسنده , , Neal D and Salter، نويسنده , , James I and Reader، نويسنده , , John C، نويسنده ,
Abstract :
Two novel solid-phase routes to the pharmaceutically relevant dibenzoxazepinone nucleus are described. In one, a key cyclisation step involves intramolecular phenolate displacement of an activated aryl fluoride. In the second, the tricyclic nucleus is prepared in solution prior to derivatisation on resin.
