Title of article :
Asymmetric Strecker synthesis by addition of trimethylsilyl cyanide to aldehyde SAMP-hydrazones
Author/Authors :
Enders، نويسنده , , Dieter and Moser، نويسنده , , Michael، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
The asymmetric 1,2-addition of trimethylsilyl cyanide to aldehyde SAMP-hydrazones in the presence of titanium tetrachloride and diethylether in dichloromethane at −100°C up to room temperature, removal of the chiral auxiliary and acid hydrolysis affords α-amino acids in high enantiomeric excesses (ee=94–97%).
Keywords :
1 , 2-addition , asymmetric synthesis , ?-Amino acids , ?-Amino nitriles , Hydrazones
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
