Title of article :
A concise stereospecific synthesis of repinotan (BAY×3702)
Author/Authors :
Gross، نويسنده , , Jonathan L.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
A concise synthesis of the 2-[aminomethyl]chroman derivative BAY×3702 (3), a potent 5-hydroxytryptamine (5-HT1A) antagonist is described. Utilization of a Mitsunobu reaction of phenol (11) with the non-racemic allylic alcohol (12) and consequent ring-closing metathesis furnishes the chroman-2-yl framework of 3 in optically active form.
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
