Title of article :
Synthesis of (−)-bestatin and the Taxotere® side-chain via nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate
Author/Authors :
Kudyba، نويسنده , , Iwona and Raczko، نويسنده , , Jerzy and Jurczak، نويسنده , , Janusz، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
The nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate 6 with 1-nitro-2-phenylethane or with phenylnitromethane led stereoselectively to adducts 4 and 12, which where then transformed into (−)-bestatin hydrochloride and the Taxotere® side-chain in overall yields of 31 and 52%.
Keywords :
nitroalcohols , nitroaldol reactions , chiral auxiliary , Asymmetric induction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
