Title of article :
Novel synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones
Author/Authors :
Cho، نويسنده , , Su-Dong and Song، نويسنده , , Sang-Yong and Park، نويسنده , , Yong-Dae and Kim، نويسنده , , Jeum-Jong and Joo، نويسنده , , Woo-Hong and Shiro، نويسنده , , Motoo and Falck، نويسنده , , J.R. and Shin، نويسنده , , Dongsoo and Yoon، نويسنده , , Yong-Jin، نويسنده ,
Abstract :
A novel and effective synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones via Smiles rearrangement is presented. Treatment of N-substituted 2-chloro(or hydroxy)acetamide, 2-tetrahydropyranyl-4-chloro-5-hydroxy(or chloro)pyridazin-3-one and cesium carbonate in refluxing acetonitrile was afforded the corresponding pyridazino[4,5-b][1,4]oxazin-3,8-diones in excellent yield.
