Title of article :
Short synthesis of a tetrasubstituted tetrahydropyran with five stereogenic centres—stereoselective double tandem rearrangements and cyclisation
Author/Authors :
Greeves، نويسنده , , Nicholas and Lee، نويسنده , , Wai-Man and McLachlan، نويسنده , , Steven P and Oakes، نويسنده , , Graham H and Purdie، نويسنده , , Mark and Bickley، نويسنده , , Jamie F، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
A stereoselective potassium hydride/18-crown-6 mediated double tandem etherification-[2,3]-Wittig-anionic oxy-Cope rearrangement was used to prepare a δ,ε-unsaturated aldehyde with syn stereochemistry. Wittig olefination, dihydroxylation and stereoselective iodine induced cyclisation completed the tetrahydropyran skeleton.
Keywords :
Iodoetherification , anionic oxy-Cope , 2 , 3]-Wittig , Ether , Sigmatropic
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
