Author/Authors :
Musicki، نويسنده , , Branislav and Periers، نويسنده , , Anne-Marie and Piombo، نويسنده , , Laurent and Laurin، نويسنده , , Patrick and Klich، نويسنده , , Michel and Dupuis-Hamelin، نويسنده , , Claudine and Lassaigne، نويسنده , , Patrice and Bonnefoy، نويسنده , , Alain، نويسنده ,
Abstract :
The design, synthesis, and biological activity in vitro of modified coumarin inhibitors of gyrase B are presented. Noviose, the sugar portion of coumarin antibiotics, was replaced by simplified mimics, a 5′,5′-dimethylcyclohexane or piperidine.
Keywords :
antibiotics , Coumarin , Noviose , Structure–activity
