Author/Authors :
Michael Leuck، نويسنده , , Michael and Giare، نويسنده , , Rubina and Paul، نويسنده , , Matthias and Zien، نويسنده , , Nicole and Wolter، نويسنده , , Andreas، نويسنده ,
Abstract :
A novel improved controlled pore glass (CPG) support based on the 2-(hydroxymethyl)-6-nitrobenzoyl (HMNB) protecting group was developed for the synthesis of 3′-aminoalkylated oligonucleotides. The release of oligonucleotides with free 3′-amino groups from the support is complete within 2 h at 55 °C in concentrated ammonia.
