Title of article
A novel solid support for the synthesis of 3′-aminoalkylated oligonucleotides
Author/Authors
Michael Leuck، نويسنده , , Michael and Giare، نويسنده , , Rubina and Paul، نويسنده , , Matthias and Zien، نويسنده , , Nicole and Wolter، نويسنده , , Andreas، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
317
To page
320
Abstract
A novel improved controlled pore glass (CPG) support based on the 2-(hydroxymethyl)-6-nitrobenzoyl (HMNB) protecting group was developed for the synthesis of 3′-aminoalkylated oligonucleotides. The release of oligonucleotides with free 3′-amino groups from the support is complete within 2 h at 55 °C in concentrated ammonia.
Keywords
Amino-ON CPG , 3?-Amino modified oligonucleotides
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656366
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