Title of article
Microwave solvent-free synthesis of nitrocyclohexanols
Author/Authors
Correc، نويسنده , , Olivier and Guillou، نويسنده , , Karine and Hamelin، نويسنده , , Jack and Paquin، نويسنده , , Ludovic and Texier-Boullet، نويسنده , , Françoise and Toupet، نويسنده , , Lo??c، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
391
To page
395
Abstract
New nitrocyclohexanols 3a–f are synthesized by a clean and original method from nitromethane 1 and unsaturated ketones 2a–f in the presence of solid potassium fluoride–alumina under solvent-free conditions coupled with microwave irradiation. The reaction involves a double and diastereoselective Michael addition followed by ring closure. Another diastereomer 3′, which differs by the configuration of C-4, is obtained in the presence of piperidine and EtOH at room temperature.
Keywords
nitrocyclohexanols , ? , ?-enones , alumina–potassium fluoride , Solvent-free reactions , Microwave activation , Michael additions
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656414
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