Title of article :
Asymmetric synthesis of macrolactin analogue
Author/Authors :
Kobayashi، نويسنده , , Yusuke and Fukuda، نويسنده , , Akihiro and Kimachi، نويسنده , , Tetsutaro and Ju-ichi، نويسنده , , Motoharu and Takemoto، نويسنده , , Yoshiji، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
Total asymmetric synthesis of macrolactin A analogue was accomplished by the convergent strategy. Rapid access to advanced intermediate 16 through isomerization of ynone to (E,E)-conjugated dienone is a key step of this synthesis. Overall, control of all of the four stereocenters was achieved by means of asymmetric and diastereoselective reactions without using any chiral natural sources.
Keywords :
asymmetric synthesis , Ynone , Isomerization , (e , E)-Conjugated dienone , macrolactin A , antibiotics , Antivirus
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
