Title of article
Design and synthesis of fluorogenic substrates that target protein phosphatases
Author/Authors
Zhu، نويسنده , , Qing and Huang، نويسنده , , Xuan and Chen، نويسنده , , Grace Y.J and Yao، نويسنده , , Shao Q، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
707
To page
710
Abstract
We have successfully designed and synthesized new fluorogenic probes that specifically target different classes of protein phosphatases. The fluorescence profiles of the probes have been studied using 12 different phosphatases, and results showed that, besides alkaline and tyrosine phosphatases, our probes were able to detect serine/threonine as well as acid phosphatases.
Keywords
high throughput , Enzyme , phosphatase , Fluorogenic , PROTEOMICS
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656630
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