Author/Authors :
Makabe، نويسنده , , Hidefumi and Miyawaki، نويسنده , , Aya and Takahashi، نويسنده , , Ryoko and Hattori، نويسنده , , Yasunao and Konno، نويسنده , , Hiroyuki and Abe، نويسنده , , Masato and Miyoshi، نويسنده , , Hideto، نويسنده ,
Abstract :
A convergent synthesis of two possible diastereomers of reticulatain-1 (1a and 1b) was accomplished. Comparison of the specific optical rotations of 1a and 1b did not allow for the strict determination of the absolute configuration. However, bis-(R)-MTPA esters of 1a and 1b showed a clear difference in chemical shifts in the 1H NMR spectra. If the bis-(R)-MTPA ester of natural reticulatain-1 (1) is available, the absolute configuration of 1 will be determined. Inhibitory action of these compounds was examined with bovine heart mitochondrial complex I. Both compounds showed almost the same activity.
