Title of article
cis-Selective synthesis of 2,5-disubstituted pyrrolidines
Author/Authors
Raziullah Hussaini، نويسنده , , Syed and Moloney، نويسنده , , Mark G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
1125
To page
1127
Abstract
A concise approach to cis-2,5-disubstituted pyrrolidines is reported, which relies upon N-tert-butoxycarbonylmethyl substitution in a substrate derived from pyroglutamic acid. The method is especially noteworthy since a significant improvement in the conditions for a key Lawesson’s reaction have been established. Regioselective enolate generation and alkylation permits extension of the C-5 side chain.
Keywords
thionation , Pyrrolidines , Lawesson’s reagent
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656913
Link To Document