Stabilization of DNA triplexes by dangling aromatic residues

Novel nucleoside analogues containing 2′-deoxyinosine and aromatic rings, which are connected by short linker groups, were synthesized and incorporated into oligodeoxyribonucleotides (ODNs). ODNs containing the nucleoside analogues formed stable duplexes and triplexes with target nucleic acids. The stacking interaction between base residues in the nucleoside analogues appears to be a major cause of stabilization.