Title of article :
Efficient modification of steroid 20S-hydroxy functionality for industrial preparation of 1α,25-dihydroxy-22-oxavitamin D3, Maxacalcitol
Author/Authors :
Shimizu، نويسنده , , Hitoshi and Shimizu، نويسنده , , Kazuki and Kubodera، نويسنده , , Noboru and Yakushijin، نويسنده , , Kenichi and Horne، نويسنده , , David A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A one-pot modification method of steroid 20S-hydroxy functionality involving sequential alkylation and reductive cleavage of epoxy bond has been established for the industrial preparation of a medicinally important 1α,25-dihydroxy-22-oxa-vitamin D3 2 (22-oxa-calcitriol), Maxacalcitol.
Keywords :
vitamin D3 , Steroid , Williamson reaction , Michael reaction , L-Selectride , one-pot reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
