Title of article
Efficient modification of steroid 20S-hydroxy functionality for industrial preparation of 1α,25-dihydroxy-22-oxavitamin D3, Maxacalcitol
Author/Authors
Shimizu، نويسنده , , Hitoshi and Shimizu، نويسنده , , Kazuki and Kubodera، نويسنده , , Noboru and Yakushijin، نويسنده , , Kenichi and Horne، نويسنده , , David A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
1347
To page
1350
Abstract
A one-pot modification method of steroid 20S-hydroxy functionality involving sequential alkylation and reductive cleavage of epoxy bond has been established for the industrial preparation of a medicinally important 1α,25-dihydroxy-22-oxa-vitamin D3 2 (22-oxa-calcitriol), Maxacalcitol.
Keywords
vitamin D3 , Steroid , Williamson reaction , Michael reaction , L-Selectride , one-pot reaction
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657046
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