Title of article
Hexafluoroacetone as a protecting and activating reagent: 5,5-difluoro- and trans-5-fluoropipecolic acids from glutamic acid
Author/Authors
Golubev، نويسنده , , Alexander S. and Schedel، نويسنده , , Hartmut and Radics، نويسنده , , Gabor and Fioroni، نويسنده , , Marco and Thust، نويسنده , , Sven and Burger، نويسنده , , Klaus، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
1445
To page
1447
Abstract
Starting from hexafluoroacetone-protected (S)-glutamic acid, trans-5-fluoropipecolic and 5,5-difluoropipecolic acid have been synthesized. The piperidine ring was constructed by an intramolecular metal carbenoid NH insertion.
Keywords
Glutamic Acid , Hexafluoroacetone , diazo ketones , DAST fluorination , Metal carbenoid NH insertion
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657116
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