مرکز منطقه ای اطلاع رساني علوم و فناوري - Hexafluoroacetone as a protecting and activating reagent: 5,5-difluoro- and trans-5-fluoropipecolic acids from glutamic acid

Title of article :

Hexafluoroacetone as a protecting and activating reagent: 5,5-difluoro- and trans-5-fluoropipecolic acids from glutamic acid

Author/Authors :

Golubev، نويسنده , , Alexander S. and Schedel، نويسنده , , Hartmut and Radics، نويسنده , , Gabor and Fioroni، نويسنده , , Marco and Thust، نويسنده , , Sven and Burger، نويسنده , , Klaus، نويسنده ,

Issue Information :

هفته نامه با شماره پیاپی سال 2004

Pages :

From page :

1445

To page :

1447

Abstract :

Starting from hexafluoroacetone-protected (S)-glutamic acid, trans-5-fluoropipecolic and 5,5-difluoropipecolic acid have been synthesized. The piperidine ring was constructed by an intramolecular metal carbenoid NH insertion.

Keywords :

Glutamic Acid , Hexafluoroacetone , diazo ketones , DAST fluorination , Metal carbenoid NH insertion

Journal title :

Tetrahedron Letters

Serial Year :

2004

Journal title :

Tetrahedron Letters

Record number :

1657116

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1657116