Title of article
Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: a novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative
Author/Authors
Matsumura، نويسنده , , Yasushi and Mori، نويسنده , , Nobuaki and Nakano، نويسنده , , Takashi and Sasakura، نويسنده , , Hideshi and Matsugi، نويسنده , , Takeshi and Hara، نويسنده , , Hideaki and Morizawa، نويسنده , , Yoshitomi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
1527
To page
1529
Abstract
A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F2α derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent.
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657171
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