Title of article :
Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: a novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative
Author/Authors :
Matsumura، نويسنده , , Yasushi and Mori، نويسنده , , Nobuaki and Nakano، نويسنده , , Takashi and Sasakura، نويسنده , , Hideshi and Matsugi، نويسنده , , Takeshi and Hara، نويسنده , , Hideaki and Morizawa، نويسنده , , Yoshitomi، نويسنده ,
Abstract :
A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F2α derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent.
