Title of article
E-1,2-Dichlorovinyl ethers as irreversible protease inhibitors
Author/Authors
Schmidt، نويسنده , , Boris and Ehlert، نويسنده , , Dennis K. and Braun، نويسنده , , Hannes A. Rüdiger، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
1751
To page
1753
Abstract
The synthesis of a novel motif for threonine protease inhibition is described. The desired E-1,2-dichlorovinyl ethers are obtained from alcohols and trichloroethylene as single diastereomers. Aqueous treatment at pH 11 unmasks the hidden α-chloroacetate, which is required for the reaction with the active site of the protease.
Keywords
Enol ether , protease
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657269
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