A novel highly regio- and diastereoselective haloamination of alkenes catalyzed by divalent palladium

From the readily available allylic alcohols or allylic amines, a novel Pd(II)–CuCl2-catalyzed haloamination reaction of alkenes with high chemo-, regio-, and diastereo-selectivity was developed. The reaction proceeds through trans-aminopalladation of alkenes, followed by oxidative cleavage of the carbon–palladium bond with retention of configuration.