Author/Authors :
Robinson، نويسنده , , Jennifer L. and Taylor، نويسنده , , Rachel E. and Liotta، نويسنده , , Lisa A. and Bolla، نويسنده , , Megan L. and Azevedo، نويسنده , , Enrique V. and Medina، نويسنده , , Irene and McAlpine، نويسنده , , Shelli R.، نويسنده ,
Abstract :
Described are the syntheses of four macrocyclic peptides that are the core structure of class B synergimycins, and the synthesis of a final class B derivative. Our synthetic route to these synergimycin derivatives allows the incorporation of amino acid substitutions at all points in the macrocycle, leading to structurally diverse class B analogs.
Keywords :
Class B , Synergimycin , antibiotic , Virginiamycin
