Title of article
Synthesis of a thioester linker precursor for a general preparation of peptide C-terminal thioacids
Author/Authors
Gaertner، نويسنده , , Hubert and Villain، نويسنده , , Matteo and Botti، نويسنده , , Paolo and Canne، نويسنده , , Lynne، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
2239
To page
2241
Abstract
A general procedure to prepare peptide thioacids by solid-phase peptide synthesis is presented. The method involves the synthesis of 4-[α-(S-acetyl)mercaptobenzyl]phenoxyacetic acid as general precursor. This reagent once attached to a solid support is derivatized with the Boc-amino acid of choice after deprotection of the thiol.
Keywords
thioacids , C-terminal modified peptides , Thioesters
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657512
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