Author/Authors :
Tandel، نويسنده , , Sagun and Bliznets، نويسنده , , Igor and Ebinger، نويسنده , , Katalin and Ma، نويسنده , , Dilip R. Bhumralkar، نويسنده , , Dilip and Thiruvazhi، نويسنده , , Mohan، نويسنده ,
Abstract :
A one-pot synthesis of 6-mercaptopurines from 4,5-diamino-6-chloro-pyrimidine, an aldehyde and elemental sulfur is presented. The key advantage of this procedure is that it utilizes the in situ generated H2S to convert the chloro to a mercapto group.
Keywords :
Thiopurines , H2S , one-pot synthesis , 4 , 5-Diamino-6-chloro-pyrimidines
