Title of article
An improved synthesis of the scyphostatin side-chain
Author/Authors
McAllister، نويسنده , , Graeme D. and Taylor، نويسنده , , Richard J.K. Taylor، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
2551
To page
2554
Abstract
A formal synthesis of the lipophilic side-chain of scyphostatin has been achieved using a convergent synthesis, in 16% yield over six steps. This synthesis involves enzymatic desymmetrisation of a meso-diol, resolution of 2-methylbutan-1-ol, stereoselective hydrozirconation of a volatile acetylene and a Negishi-style cross coupling.
Keywords
stereoselective synthesis , enzymes , desymmetrisation , cross-coupling , natural products
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657663
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