Title of article :
Tandem amine propargylation-Sonogashira reactions: new three-component coupling leading to functionalized substituted propargylic amines
Author/Authors :
Olivi، نويسنده , , Nathanaël and Spruyt، نويسنده , , Philippe and Peyrat، نويسنده , , Jean-François and Alami، نويسنده , , Mouâd and Brion، نويسنده , , Jean-Daniel، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
Three-component coupling reactions of propargyl halides, amines, and organic halides in the presence of palladium–copper catalysis produced efficiently highly functionalized propargylic amines in good to excellent yields at room temperature. Extension to the synthesis of 2-(dialkylaminomethyl)benzo[b]furan or indole derivatives is described.
Keywords :
Sonogashira , Propargyl halides , Propargylic amines , PALLADIUM , 2-(Dialkylaminomethyl)indoles , 2-(Dialkylaminomethyl)benzofuranes
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
