Author/Authors :
Adele Cutignano، نويسنده , , Adele and Cimino، نويسنده , , Guido and Giordano، نويسنده , , Antonella and d’Ippolito، نويسنده , , Giuliana and Fontana، نويسنده , , Angelo، نويسنده ,
Abstract :
The paper reports the biosynthesis of the main alkylpyridine alkaloids, haminol-1 (1) and -2 (2), in the Mediterranean mollusc Haminoea orbignyana. Experiments were carried out by in vivo incorporation of [1,2- 13C2 acetate]. Data give full account for a polyketide origin of haminols in the Mediterranean molluscs, showing the biosynthesis of these 3-alkylpyridine alkaloids by elongation with acetate of a starter unit of nicotinic acid.
