Synthesis of novel cationic cardiolipin analogues for the optimal delivery of therapeutic agents

A novel approach was developed to synthesize cardiolipin analogues containing two quaternary ammonium groups with tetraalkyl chain retaining ‘glycerol’ moiety, the central core of the molecule. The analogues were synthesized with or without spacer and/or lipid chain length with saturation to tailor lipid-based formulations of therapeutic agents for optimal delivery to target sites.