Regio- and stereochemistry of inter- and intramolecular titanium-mediated coupling of imides and mono-substituted olefins

The intramolecular titanium-mediated coupling reaction of α-substituted succinimides and mono-substituted olefins took place with complete regiocontrol, but without diastereoselectivity. The corresponding intermolecular coupling exhibited lack of regio- and diastereocontrol. Also included were stereochemical studies of catalytic hydrogenation and NaBH3CN reduction of the cyclization products.