Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units

The synthesis of a novel dendron and dendrimer with potential application in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is described. The dendrimer branching unit was designed to have structural similarities to cinnamic acid based matrices used in MALDI MS. Branching was incorporated into the structure by introducing a second acrylic acid side chain. Some intermediates of the monomer synthesis were shown to function as MALDI matrices. A second-generation dendron was assembled on a solid support employing an N-to-C directed convergent synthetic strategy. Coupling of the dendrons with a trivalent core molecule resulted in a second generation dendrimer.