Title of article
The homologation of histidine
Author/Authors
Kumar، نويسنده , , Amit and Ghilagaber، نويسنده , , Stephanos and Knight، نويسنده , , Jamie and Wyatt، نويسنده , , Peter B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
6991
To page
6994
Abstract
(S)-3-Amino-4-[(1H)imidazol-4-yl]butanoic acid (1), a β-amino acid which is a homologue of l-histidine, has been synthesised in five steps from l-histidine methyl ester. The presence of N(α)- and N(Im)-2,4,6-trimethylbenzenesulfonyl protecting groups was crucial to the success of the route, the key step of which involved the ring opening of an aziridine intermediate by sodium cyanide.
Keywords
Aziridines , amino acids and derivatives , imidazoles , protecting groups
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658194
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