1,4-Bis-(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane from the direct tosylation of 1,4,7,10-tetraazacyclododecane

The reaction between 1,4,7,10-tetraazacyclododecane and 4-toluenesulphonyl chloride in triethylamine/chloroform yields both the disubstituted isomers of bis-(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane. This has been confirmed by 1H NMR and X-ray crystallographic analyses.