Title of article :
Parallel synthesis of 1,2,4-trisubstituted imidazoles via N-alkyl-N-(β-keto)amides using a carbazate linker
Author/Authors :
Cobb، نويسنده , , James M. and Grimster، نويسنده , , Neil and Khan، نويسنده , , Nawaz and Lai، نويسنده , , Justine Y.Q. and Payne (née Gold)، نويسنده , , Helen J. and Payne، نويسنده , , Lloyd J. and Raynham، نويسنده , , Tony and Taylor، نويسنده , , Jess، نويسنده ,
Abstract :
The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N-alkyl-N-(β-keto)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N-alkyl-N-(β-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solution using NH4OAc led to the preparation of 1400 1,2,4-trisubstituted imidazoles.
Keywords :
1 , N-alkyl-N-(?-keto)amide , 2 , 4-trisubstituted imidazole , Solid phase synthesis , carbazate linker
