Author/Authors :
Li، نويسنده , , Zhaoming and Zhou، نويسنده , , Zhenghong and Li، نويسنده , , Kangying and Wang، نويسنده , , Lixin and Zhou، نويسنده , , Qilin and Tang، نويسنده , , Chuchi Tang، نويسنده ,
Abstract :
A practical method for the synthesis of β-hydroxymercaptans has been successfully developed through the ring-opening of epoxides with organic dithiophosphorus acids 1. Highly regio- and stereoselective products, β-hydroxyalkyl dithiophosphates, which were transformed to the corresponding synthetically valuable β-hydroxymercaptans by further reduction, were obtained under mild reaction conditions without any catalyst or promoter. Highly enantioselective ring-opening reaction of cyclohexene epoxide with 1 was realized in the presence of a chiral (salen)Ti(IV) complex.
