Author/Authors :
Ramig، نويسنده , , Keith and Englander، نويسنده , , Miriam and Kallashi، نويسنده , , Florida and Livchits، نويسنده , , Lilia and Zhou، نويسنده , , Jessica، نويسنده ,
Abstract :
The trifluoromethyl group of certain compounds containing one or two trifluoromethyl groups can be converted to the carbomethoxy group by treatment with sodium methoxide followed by aqueous acidic work-up. α-Trifluoromethyl esters can be obtained by selective methanolysis of the 1,1,1,3,3,3-hexafluoroisopropyl group in some cases. The structural requirements for the transformation are delineated, and a mechanistic study confirms the proposed mechanism, a dehydrofluorination–addition–elimination process.
