Regulation of one-electron oxidation rate of guanine and hole transfer rate in DNA through hydrogen bonding

The effects of methyl and bromo groups at C5 of C on the one-electron oxidation rate of G, and on the hole transfer rate in DNA have been investigated. The rates of one-electron oxidation of G and hole transfer from Py+ to 8-oxo-7,8-dihydroguanine were suppressed and enhanced by introducing bromo and methyl groups, respectively, on the C at the complementary strand.