Title of article
First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720
Author/Authors
Klaus Hinterding، نويسنده , , Klaus and Albert، نويسنده , , Rainer and Cottens، نويسنده , , Sylvain، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
8095
To page
8097
Abstract
FTY720 is an immunosuppressant with a novel mode of action and is highly effective in animal models of transplantation and autoimmunity. Herein we describe the first asymmetric synthesis of chiral FTY720 analogues using the Schِllkopf-protocol. We also describe a practical synthesis of the corresponding phosphates, which are essential tools for elucidation of FTY720ʹs mechanism of action.
Keywords
immunosuppressant , FTY720 , Schoellkopf-auxiliary , phosphates
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658862
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