Author/Authors :
Murata، نويسنده , , Yoshihisa and Kamino، نويسنده , , Tomoyuki and Hosokawa، نويسنده , , Seijiro and Kobayashi، نويسنده , , Susumu، نويسنده ,
Abstract :
Development of an enantio- and stereoselective construction of 1,2-diols including a quaternary chiral center was achieved by a titanium-mediated aldol reaction of lactates bearing chiral oxazolidine-2-ones. anti-Aldol and syn-aldol were selectively obtained by the choice of a benzyl and TBS protecting group, respectively. Plausible transition states are also shown based on the stereochemistry of the enolate anion.
