Author/Authors :
Gaucher، نويسنده , , Anne and Barbeau، نويسنده , , Olivier and Hamchaoui، نويسنده , , Wahib and Vandromme، نويسنده , , Lucie and Wright، نويسنده , , Karen and Wakselman، نويسنده , , Michel and Mazaleyrat، نويسنده , , Jean-Paul، نويسنده ,
Abstract :
Terminally protected Boc-β3-(L)-DOPA-OMe has been synthesized from (L)-DOPA by the Arndt–Eistert homologation procedure. Then, a first crown-ether derivative, Boc-[18-C-6]-β3-(L)-DOPA-OMe, has been obtained by bis-O-alkylation of the catechol function with cyclization, using Cs2CO3 as base and pentaethyleneglycol ditosylate as alkylating agent, in DMF at 60°C.
Keywords :
?-Amino acids , ?-Peptides , ?3-(L)-DOPA , Crown-ethers
