Title of article
New azadisaccharide analogs as potential antidiabetics
Author/Authors
Christine Gravier-Pelletier، نويسنده , , Christine and Maton، نويسنده , , William and Le Merrer، نويسنده , , Yves، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
8285
To page
8288
Abstract
The synthesis of various aminocyclitols displaying a N-substituted (or unsubstituted) polyhydroxycyclohexylamine structure is described. The strategy relies on two key steps: a tandem alkylation–cyclization of a C2-symmetrical bis-epoxide derived from d-mannitol and a reductive amination with several amines of the resulting polyhydroxycyclohexanone. Reduction of the latter also allows a rapid access to the corresponding carbasugars.
Keywords
glycosidases , pseudo-azasaccharide , Carbasugars , reductive amination , aminocyclitols
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658985
Link To Document