Title of article
A one-flask synthesis of α,α-bisphosphonates via enolate chemistry
Author/Authors
Du، نويسنده , , Yanming and Jung، نويسنده , , Kang-Yeoun and Wiemer، نويسنده , , David F.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
8665
To page
8668
Abstract
Treatment of several carbonyl compounds with excess strong base and diethyl phosphorochloridite results in formation of two carbonphosphorus bonds at the α carbon. Oxidation of the immediate product with H2O2 affords the corresponding α,α-bisphosphonate in moderate to very good yields.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659200
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