Author/Authors :
Hecht، نويسنده , , Stefan and Amslinger، نويسنده , , Sabine and Jauch، نويسنده , , Johann and Kis، نويسنده , , Klaus and Trentinaglia، نويسنده , , Viola and Adam، نويسنده , , Petra and Eisenreich، نويسنده , , Wolfgang and Bacher، نويسنده , , Adelbert and Rohdich، نويسنده , , Felix، نويسنده ,
Abstract :
(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-d-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-3H]-6 and [1-2H1]-6 from the same starting material in four steps where the hydrogen isotope is introduced in the last reaction step from deuterated or tritiated sodium borohydride. The radiochemical yield of [1-3H]-6 was 15%.
