Author/Authors :
Jaramillo، نويسنده , , Carlos and Carretero، نويسنده , , Juan Carlos and de Diego، نويسنده , , J.Eugenio and del Prado، نويسنده , , Miriam and Hamdouchi، نويسنده , , Chafiq and Rold?n، نويسنده , , José Luis and S?nchez-Mart??nez، نويسنده , , Concha، نويسنده ,
Abstract :
A convenient synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridines 3 is described. A halogen–metal exchange study on building block 1 showed that use of i-propyl magnesium chloride is most effective for chemoselective functionalization at position 6. Further regiospecific metalation at position 3, followed by quenching with different electrophiles, afforded target compounds.
