Author/Authors :
Vielle، نويسنده , , Sophie and Raimbaud، نويسنده , , Eric and Bertrand، نويسنده , , Philippe and Quintard، نويسنده , , Delphine and Renard، نويسنده , , Pierre and Pfeiffer، نويسنده , , Bruno and Gesson، نويسنده , , Jean-Pierre، نويسنده ,
Abstract :
Starting from the X-ray structure of epothilone B, an original, non macrocyclic, structure has been designed to mimic the key structural features of this potent anticancer agent; the preparation of a key intermediate incorporating four stereogenic centers is described from cyclohexane-1,3-dione.
