Author/Authors :
Ashwood، نويسنده , , Michael S. and Cottrell، نويسنده , , Ian F. and Cowden، نويسنده , , Cameron J. and Wallace، نويسنده , , Debra J. and Davies، نويسنده , , Antony J. and Kennedy، نويسنده , , Derek J. and Dolling، نويسنده , , Ulf H.، نويسنده ,
Abstract :
A facile process for the preparation of substituted ethyl 2′-pyridyldifluoroacetates 3 is described starting from readily available ethyl bromodifluoroacetate 2 and substituted 2-bromo or 2-chloropyridines 1. This process features a copper-mediated cross-coupling reaction in DMSO and is the first to utilise pyridylbromides or chlorides with ethyl bromodifluoroacetate 2 in this reaction.
