Conjugate addition of amines to vinyl sulfoximides: a general method for the synthesis of β-amino sulfoximides

The synthesis of a range of β-amino sulfoximide derivatives is described. The conjugate addition of simple amines or amino acids to N-tosyl phenyl vinyl sulfoximide was achieved in moderate to good yield (41–95%). Electron poor nucleophiles such as tosyl amide or benzyl carbamate were found to be unreactive under analogous conditions.