Author/Authors :
Dumas، نويسنده , , Françoise and Thominiaux، نويسنده , , Cyrille and Miet، نويسنده , , Christine and dʹAngelo، نويسنده , , Jean and Desmaële، نويسنده , , Didier and Nour، نويسنده , , Mohammed and Cavé، نويسنده , , Christian and Morgant، نويسنده , , Georges and Tran Huu-Dau، نويسنده , , Marie-Elise، نويسنده ,
Abstract :
An unusual process takes place during the lithium–ammonia reduction of a variety of cyclic enones bearing an ester group in the γ-position, furnishing cyclopropanols. The reason for this unprecedented outcome has been attributed to the through-space stabilization of a developing cyclopropyl radical by interaction with the neighboring ester substituent.
Keywords :
Reduction , radical and radical reactions , molecular modeling/mechanics , Cyclopropanation , enones
